BiOasis's Herceptin(R) Designed To Treat Brain Metatastsis Of HER2+ Breast Cancer Growth Tumors In Xenograft

VANCOUVER, BRITISH COLUMBIA--(Marketwire - Sept. 5, 2012) - biOasis Technologies Inc. (TSX VENTURE:BTI.V - News) appear today that a key beastly abstraction in its BT2111 oncology program, showed that BT2111, biOasis' conjugate of trastuzumab (Herceptin(R)) advised to amusement academician metatastsis of HER2+ breast cancer, arrests the advance tumors in a xenograft archetypal of animal breast carcinoma. The animal bump xenograft archetypal is accustomed industry-wide as a gold accepted for assessing the achievement of new and arising drugs to amusement cancer. The archetypal is declared here:

Briefly, a awful advancing animal breast blight was crude subcutaneoulsy into almsman animals. The animals were advised alert per anniversary for 6 weeks with either BT2111, Herceptin(R) or a placebo. Each anniversary the bump volumes were measured. In the placebo ascendancy animals, the tumors added in admeasurement by 400% over baseline. In both the BT2111 and Herceptin(R) advised groups, the bump advance was absolutely halted. Further, both Herceptin(R) and BT2111 were able-bodied acceptable with no credible signs of toxicity.

"Over the accomplished year the Herceptin(R)-BT2111 conjugate affairs has delivered some aberrant after-effects for biOasis," says Rob Hutchison, CEO. "The abutting basic footfall for us in our BT2111 program, was to appraise its achievement in this blight xenograft study. In this study, we were able to analyze anon the Herceptin(R)-BT2111 conjugate to Herceptin(R) alone. The after-effects demonstate that the Herceptin(R)-BT2111 conjugate is as alive as, and at several timepoints exceeded Herceptin(R), in endlessly bump growth. Herceptin(R) is a potentailly life-saving analysis that reduces the recurrance of HER2+ breast blight amid women adeptness chemotherapy. Unfortunately, this biologic is afar from the academician and is appropriately abortive for alleviative women with academician alteration of HER2+ breast cancer. We accept announed ahead that a ample allotment of intravenously administered Herceptin(R)-BT2111 conjugate enters the accurateness of beginning animals. Our abutting footfall is to authenticate in accord with Texas Tech University that our Herceptin(R)-BT2111 conjugate is active in endlessly the advance of academician metastases of breast cancer." For added advice on this, bang this video articulation "xenograft" on the biOasis home folio -

ABOUT BT2111 - BT2111 is a conjugate amid biOasis' Transcend academician commitment agent and trastuzumab (trade name of Herceptin(R)), a humanized monoclonal antibiotic acclimated clinically in the analysis of HER2+ breast cancer. It is appear that up to 30% of HER2+ breast blight patients advance academician alteration for which ameliorative options are limited. Because of its adeptness to cantankerous the blood-brain barrier, biOasis is researching the abeyant of BT2111 for analysis of HER2+ metastatic breast blight in the brain.

Herceptin(R) is a registered brand of Roche/Genentech.


biOasis Technologies Inc. is a biopharmaceutical aggregation headquartered in Vancouver, Canada. Based on Transcend, biOasis proprietary academician commitment platform, the Aggregation is focused on creating new drugs that can cantankerous the blood-brain barrier to abode unmet medical needs in the analysis of academician diseases such as neurodegeneration, metastatic blight and metabolic diseases. biOasis trades on the TSX Venture Exchange beneath the attribute "BTI". For added advice about the Aggregation please appointment

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On Behalf of the Board of Directors

Rob Hutchison Chairman & CEO

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