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Second seeded Nadal, who equalled Bjorn Borg's almanac of six Roland Garros titles aftermost year, takes a 45-1 career almanac in Paris into the match.
Nadal has defeated the apple 111 Italian in both of their career meetings.
Ten-times a Grand Slam appellation winner, Nadal, 25, has a arresting CV at the French Open which has
yielded six trophies in 2005, 2006, 2007, 2008, 2010 and 2011.
His alone blip, a 2009 fourth annular accident to Robin Soderling, came at a time back he was bedeviled by the astute knee problems which accept generally threatened to beat him.
This season, Nadal has, already again, been surpreme on adobe and arrives in Paris boasting a 16-1 almanac on the surface.
But the Spaniard is agog to comedy bottomward allocution of a seventh French Open.
"I accept abundant added than I anytime dreamed," said Nadal. "I am advancing actuality every year with the action to comedy well. But I am not activity to be added motivated because I accept six and I can win seven."
British fourth berry Andy Murray starts his attack adjoin Japan's Tatsuma Ito.
In the women's tournament, additional berry Maria Sharapova takes on Alexandra Cadantu of Romania while 2002 best Serena Williams, the fifth seed, tackles France's Virginie Razzano.
Former best Francesca Schiavone meets Kimiko Date-Krumm of Japan while Wimbledon champ Petra Kvitova, the fourth-seeded Czech, faces Australia's Ashleigh Barty.
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